Jacob Wesley Ulm, MD, PhD


Resumé and Annotated Summary of Publications


 LinkedIn URL and contact: https://www.linkedin.com/in/j-wes-ulm-5a347166

Objective: Developing innovative tools in bioinformatics (data-mining and pattern recognition), genetics, and gene therapy toward advances in novel therapeutics and translational medicine


____________________________________HIGHLIGHTS_______________ _____   _______

Language proficiencies (spoken)

Fluent (full professional proficiency, oral and written communication): Mandarin Chinese (experience as medical volunteer in China, hospital externship in Taiwan, presenter of popular online Mandarin lectures in genetics and molecular biology), Spanish, German

Advanced professional working proficiency (oral and written): Portuguese, French, Dutch

Limited working proficiency (oral and written): Japanese, Russian, Italian

Elementary proficiency (oral), limited working proficiency (written): Danish, Swedish, Farsi Persian, Tagalog

(programming and scripting)

High-level proficiency with extensive professional working experience: Python, R

Significant proficiency with working experience: Matlab, Pascal, Perl

Basic proficiency with familiarity (currently learning and mapping syntax and data structures based on previously learned programming languages)

Java, C++, C#, Javascript, HTML5, SQL, Ruby



      ____________________________________EDUCATION________________ _____   ______

HARVARD MEDICAL SCHOOL AND MIT                                Boston, MA       

Joint MD/PhD Program                                                                                              1996-2006

MD with PhD in Genetics and Gene Therapy


DUKE UNIVERSITY                                                                        Durham, NC

Bachelor of Science in Chemistry and Biochemistry (summa cum laude)         1992-1996






______________________  WORK AND RESEARCH EXPERIENCE____         _____   ___ 

CEDARS-SINAI MEDICAL CENTER/UCLA                               Los Angeles, CA



MY TUTOR                                                                             Los Angeles, CA



THE WASHINGTON POST COMPANY                             Multi-site



INDEPENDENT CONTRACTOR                                                               Multi-site



UCLA, CEDARS-SINAI,                                                         Greater Los Angeles Area, CA

OLIVE VIEW HOSPITALS                                                                        6/2006-9/2009

·        Resident physician successfully completed internship requirements and passed United States Medical Licensing Examination (USMLE) Step III on first attempt

o   Case report on zoonotic bacterial infection in post-renal transplant pediatric patients, published in J Pediatr Inf Dis


HARVARD MEDICAL SCHOOL/MIT                                  BOSTON, MA



DUKE UNIVERSITY                                                                        DURHAM, NC




______________________             PERSONAL___                                 _       _____   ___ 



Annotated Summary of Publications


Section 1:  Refereed and published papers, book chapters for specialized readership in biomedical field (not including PhD thesis dissertation)


“Complex determinants within the Moloney murine leukemia virus capsid modulate susceptibility of the virus to Fv1 and Ref1-mediated restriction.”  Ulm JW, Perron M, Sodroski J, Mulligan RC.  Virology. 2007 Jul 5;363(2):245-55.  


TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells.”  Perron MJ, Stremlau M, Song B, Ulm W, Mulligan RC, Sodroski J.  Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11827-32.


Authorship of two chapters (text and figures) on gene therapy principles, relevant modern techniques, and disease targets for Encyclopedia of Genetics, Genomics, Proteomics, and Bioinformatics, published September 2005 (John Wiley & Sons, Ltd.): Gene Therapy I:  Principles and Clinical Applications and Gene Therapy II:  Viral vectors and treatment modalities.


Co-authorship of Chapter 53, “Protein-based and gene therapies,” with contribution (text and figures) on gene therapy pharmaceuticals, vectors, disease targets, and novel modalities in textbook, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, edited by Dr. David Golan, Department of Pharmacology, Harvard Medical School; Lippincott Williams & Wilkins, April 2004


“Online Self-Report Data for Duchenne Muscular Dystrophy Confirms Natural History and Can Be Used to Assess for Therapeutic Benefits.” Wang RT, Silverstein Fadlon CA, Ulm JW, Jankovic I, Eskin A, Lu A, Rangel Miller V, Cantor RM, Li N, Elashoff R, Martin AS, Peay HL, Halnon N, Nelson SF. PLOS Currents Muscular Dystrophy. 2014 Oct 17. Edition 1. doi: 10.1371/currents.md.e1e8f2be7c949f9ffe81ec6fca1cce6a.


Acinetobacter bacteremia following a hamster bite in a child with history of kidney transplant.”  Azaran B, Puliyanda D, Ulm JW, Equils O.  J Pediatr Infect Dis, 2010;5(3);158-163. doi: 10.3233/JPI-2010-0252


“Development and application of novel pattern recognition-based data-mining tools toward the identification of promising candidates for DMD drug repurposing: a pilot feasibility study” (report in progress)


“Categorical data-based comprehensive review of literature on therapeutic development for Duchenne Muscular Dystrophy from positional cloning of the dystrophin gene to the present” (report in progress)


Section 2: Conference papers for specialized audiences in biomedical field


“Incorporation of Novel Categorical Data Parsing and Pattern-Recognition Tools in the Mining and Development of New Pharmacological Strategies for DMD Treatment and Management.” Abstract for 2016 UCLA Genetics Academic Retreat, American Society for Human Genetics, and Center for Duchenne Muscular Dystrophy annual meetings.


“Integrated Data-Aggregation and Mining Systems to Improve Detection of Meaningful Associations in DMD.” Abstract for 2015 UCLA Genetics Academic Retreat, American Society for Human Genetics, and Center for Duchenne Muscular Dystrophy annual meetings.


Online DuchenneConnect self-report data indicates Exon 44 skippable DMD patients have prolonged wheelchair free survival.” Abstract for 2014 UCLA Genetics Academic Retreat, American Society for Human Genetics, and Center for Duchenne Muscular Dystrophy annual meetings.


“Herpesvirus Amplicon-based siRNA-expressing Vectors as a Therapeutic Strategy for Neurofibromatosis Type 1,” prize-winning (international 2nd prize) research proposal for 2003 International NF Research Competition for Graduate Students and Postdoctoral Fellows, National Neurofibromatosis Foundation (NNFF), with subsequent invitation to NNFF International Consortium for the Molecular Biology of NF1 and NF2, May 2004 in Aspen, Colorado.


AAV and HSV Amplicon-based si-RNA Expression Vectors as Therapeutic Modalities for Drug-Resistant Cancers.”  Abstract for 2004 International Society for Cancer Gene Therapy conference in Singapore, Cancer Gene Therapy 11, 859 - 860 (01 Dec 2004).


“Application of fast step-scan Fourier-transform infrared absorption-difference time-resolved spectroscopy (S2 FT-IR DA TRS) to examine association-dissociation kinetics of carbon monoxide and hemoglobin.” Abstract and oral presentation for American Chemical Society conference in North Carolina, spring 1996.



Section 3: Thesis dissertation and technical works for non-specialized audiences


PhD Thesis dissertation:  Elucidation of retroviral capsid residues involved in modulation of murine and human cell post-entry restriction.  Approved November 2004, published in bound form (167 pages) April 2006, Graduate School of Arts and Sciences, Harvard Medical School.


Sole author of Fundamentals of Computer Science: A Study Guide, approx. 200-page problems workbook and guide for introductory computer science courses (algorithm design and Pascal programming), to accompany Great Ideas in Computer Science, textbook written by Dr. Alan Biermann of the Duke University Department of Computer Science; published at MIT Press, May 1996, and used at several universities nationwide.


Publication of research article on synthesis and kinetics of 3-deoxy-D-manno-octulosonic acid (KDO) and implications for novel gram-negative bacteria-specific antimicrobials in Vertices, Duke student science and technology magazine, Spring 1995 issue.